The new Forgotten Realms books are set after Baldur's Gate 3 and show Karlach found her happy ending, though one jerk wizard also dodged his comeuppance

The idea of "canonicity" in RPGs is an odd one, given the whole point of both videogame and tabletop RPGs is that the players decide what the main characters do. But sequels, spin-offs, and sourcebooks have a habit of choosing particular outcomes as the "real" ones—unless it's the Elder Scrolls, where every ending of Morrowind happened at once...
Read more.