Skyrim Anniversary Edition is causing crashes by running too efficiently

In preparation for Skyrim Anniversary Edition, and the modpocalypse expected to follow its release, I trimmed my mod load down to a respectable handful. Essentials like Alternate Start - Live Another Life and some additional followers, including Inigo and Lucien. I started a new game and everything was fine, until I quit to do some actual work and then tried to reload that game on my lunch break. A black screen, with the music still playing, was all I got...
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